Use the brief to make the comparison fair.
Start with the demand you can see
If the product is new, separate the sample or pilot quantity from the first repeatable production order. That gives the team a chance to validate fit and finish before committing to a large run.
Ask what changes the minimum
Tooling, paper sourcing, print setup, assembly and insert materials can influence the minimum quantity. A supplier should explain which part of the specification is driving the number.
Keep the first box practical
For an early run, reduce unnecessary mechanisms and finishes. A clear structure with a well-fitted insert gives you a strong base for the next version.
Plan for the repeat order
Keep approved artwork, board, color references and packaging specifications together. Repeatability matters when your next order has a different quantity or delivery split.